Principal Investigator: Assoc Prof Lanry Yung Lin-Yue
Team Members: Dr Ang Yan Shan, Dr Norman Teo Zhi Wei, Dr Wu Shuang
BioDetectIF aims to accelerate drug discovery via our proximity assay which enables the direct measurement of drug-target interactions in translatable systems. Drug discovery is a time consuming (> 10 years) and expensive (billions of dollars) process. Yet on average, only one in every 5,000 compounds selected for pre-clinical development is successfully developed as an approved drug. This figure can be improved if the compound selection decisions were supported by sound proof-of-mechanism evidence. Here, we offer a no-wash solution-phase assay which provides reliable and direct insight into drug-target binding within 30 minutes even for in vivo models. Compared to the existing protein melting method and cell-based assay, our assay is cost-effective, rapid and much simpler without the need for complicated vector design or controlled sample heating. Furthermore, it can be easily integrated into existing automation workflow based on microplate reader and high content screening systems.
Principal Investigator: Asst Prof Terry Steele
Team Members: Dr Ivan Djordjevic, Karen Harazimova, Prakhar Prakash
CaproGlu is an adhesive, hypoallergenic aesthetic ‘film forming polymer’ for next generation cosmetic solutions. CaproGlu is a liquid, oil-like substance that turns into an elastic biodegradable film after exposure to sunlight. An elastic film adheres to tissues by formation of interfacial chemical bonds. This feature makes CaproGlu an ideal component in cosmetic products, such as: waterproof sunscreens, perfumes, hair treatment formulations, make up, nail polish, etc. The cosmetics market growth is driven by innovation and consumers demand for quality-of-life enhancing products. CaproGlu’s innovative technology offers value-added future cosmetics with scientific advantages to the prestige brands. An additional advantage is that CaproGlu provides longer lasting cosmetics with compatible price and minimal risk of allergies or skin irritation.
Principal Investigator: Asst Prof Shao Huilin
Team Members: Dr Nicholas Ho, Ram Gottipati
EnVision is a nucleic acid-based rapid disease diagnostic kit that offers easy-to-interpret colour readouts within an hour. The test kit was developed for point of care testing, hence it utilizes unique chemistry that allows for equipment-free operation at room temperature. Its versatile chemistry can be easily and rapidly redesigned to detect nucleic acid biomarkers of diseases, and it achieved comparable performance as the gold standard clinical assay in identifying different HPV subtypes in a pilot study with patient samples. We are looking into using this technology for time-critical diagnoses in the hospital and decentralized clinic setting, such as sepsis, antimicrobial identification, and drug resistance testing.
Principal Investigator: Assoc Prof Sierin Lim
Team Members: Dr Mridul Sarker, Maanasa G, Nikhil Rungta
Skin is the largest organ of the human body and it also forms the basis of various transdermal applications. Despite its importance and functionality, transdermal delivery of active foreign molecules or drugs remains a challenge for manufacturers of personal care and therapeutic industries because current delivery technologies are limited in terms of skin permeability and cell-specific delivery. Thus, there is a growing need to solve these problems and help products reach their true efficacy.
Nature-derived protein nanocage has been identified as a nano-structured delivery vehicle that aids the delivery of active ingredients through the skin. The protein nanocage is capable of encapsulating the active ingredient of a given product and enhancing its targeting and penetration capabilities.
Team Protein Nanocage aims to solve the bane of skin-centric industries with this revolutionary technology and expand the scope of this novel delivery vehicle to other applications.
Soft Microtubular Sensors
Principal Investigator: Prof Lim Chwee Teck
Team Members: Yu Longteng, Oh Chinlock, Mart Vos, Zhao Shichen
We develop ultrathin elastomeric microtubes and design microtubular sensors for a wide range of applications including robotics, consumer electronics, internet of things (IoT), disease sensing and rehabilitation monitoring. With multiple patents filed, our ultrathin, highly stretchable, flexible, weavable and washable microtubular sensors have great potential for next-generation devices for robotics, consumer electronics, IoT and precision health. Here in Lean LaunchPad, we explore the business of using the microtubular sensor to achieve continuous pressure monitoring during compression therapy for venous ulcer, etc. We believe our technology can improve the efficacy of current compression therapy, shorten the healing process, facilitate the training process of specialized nurses and therefore reduce the cost of both patients and hospitals.